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Phenotype Image Detail
Caption In four week old mice, hematoxylin and eosin staining of control and Sox2tm1.1Lan/Sox2tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0 (Sox2delta/delta) lung sections demonstrated abnormal low cuboidal-to-squamous epithelium in large bronchioles (A, B) and small bronchioles (C,D). Immunohistochemical staining demonstrated loss of CCSP (Scgb1a1) a Clara cell marker (E,F), ciliated cell markers alpha-tubulin and FoxJ1 (G-J). Lung epithelial markers Nkx2.1 and FoxA2 were unchanged in control vs mutant mice (K-N). Arrows indicate regions shown in insets. Scale bar is 50 um, inset scale bar is 10 um.
Copyright This image is from Tompkins DH, PLoS One 2009;4(12):e8248, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155963
Symbol Name
Sox2tm1.1Lan SRY (sex determining region Y)-box 2; targeted mutation 1.1, Richard A Lang
Allelic Composition Genetic Background
involves: 129/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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