Phenotype Image Detail

Image

Caption

In four week old mice, hematoxylin and eosin staining of control and Sox2^tm1.1Lan/Sox2^tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0 (Sox2^delta/delta) lung sections demonstrated abnormal low cuboidal-to-squamous epithelium in large bronchioles (A, B) and small bronchioles (C,D). Immunohistochemical staining demonstrated loss of CCSP (Scgb1a1) a Clara cell marker (E,F), ciliated cell markers alpha-tubulin and FoxJ1 (G-J). Lung epithelial markers Nkx2.1 and FoxA2 were unchanged in control vs mutant mice (K-N). Arrows indicate regions shown in insets. Scale bar is 50 um, inset scale bar is 10 um.

This image is from Tompkins DH, PLoS One 2009;4(12):e8248, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155963

Associated
Alleles

Symbol	Name
Sox2^tm1.1Lan	SRY (sex determining region Y)-box 2; targeted mutation 1.1, Richard A Lang

Associated
Genotypes

Allelic Composition	Genetic Background
Sox2^tm1.1Lan/Sox2^tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0	involves: 129/Sv * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23