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Phenotype Image Detail
Image
Caption Hematoxylin and Eosin staining of sections of renal cortex from wild-type (WT), Ptgs2tm1Unc/Ptgs2tm1Unc (COX-2 null) and Ptgs2tm1.1Wls/Ptgs2tm1.1Wls (Delta18 COX-2) mice. Kidneys were harvested from mice after euthanasia and fixed in 10% formalin in phosphate-buffered saline, pH 7.4. Kidneys were embedded in paraffin for staining with H & E. A. Renal cortex from WT mouse. B. Renal cortex from Ptgs2tm1Unc/Ptgs2tm1Unc mouse. C. Renal cortex from Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mouse. (Original magnification, x 200) Arrows indicate glomeruli. The results show that the renal cortex in Ptgs2tm1Unc/Ptgs2tm1Unc mice exhibit glomerular hypoplasia and hypertrophy of glomeruli as reported previously, but sections from renal cortex of WT and Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mice are morphologically indistinguishable.
Copyright This image is from Wada M, J Biol Chem 2009 Nov 6;284(45):30742-53 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156331
Associated
Alleles
Symbol Name
Ptgs2tm1.1Wls prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, William L Smith
Ptgs2tm1Unc prostaglandin-endoperoxide synthase 2; targeted mutation 1, University of North Carolina
Associated
Genotypes
Allelic Composition Genetic Background
Ptgs2tm1Unc/Ptgs2tm1Unc B6;129P2-Ptgs2tm1Unc/Tac
Ptgs2tm1.1Wls/Ptgs2tm1.1Wls B6.129-Ptgs2tm1.1Wls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory