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| Caption | Hematoxylin and Eosin staining of sections of renal cortex from wild-type (WT), Ptgs2tm1Unc/Ptgs2tm1Unc (COX-2 null) and Ptgs2tm1.1Wls/Ptgs2tm1.1Wls (Delta18 COX-2) mice. Kidneys were harvested from mice after euthanasia and fixed in 10% formalin in phosphate-buffered saline, pH 7.4. Kidneys were embedded in paraffin for staining with H & E. A. Renal cortex from WT mouse. B. Renal cortex from Ptgs2tm1Unc/Ptgs2tm1Unc mouse. C. Renal cortex from Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mouse. (Original magnification, x 200) Arrows indicate glomeruli. The results show that the renal cortex in Ptgs2tm1Unc/Ptgs2tm1Unc mice exhibit glomerular hypoplasia and hypertrophy of glomeruli as reported previously, but sections from renal cortex of WT and Ptgs2tm1.1Wls/Ptgs2tm1.1Wls mice are morphologically indistinguishable. | ||||||
| Copyright | This image is from Wada M, J Biol Chem 2009 Nov 6;284(45):30742-53 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156331 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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