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| Caption | Regions with abnormal microstructure in Tor1atm2Wtd/Tor1a+ mice. (A) Three-dimensional display of regions with abnormal white matter microstructure in the mutant animals. Significant reductions (P < 0.0001, Student t test) in fractional anisotropy (FA) were present in the following brain areas: superior cerebellar tract (marked by "1"), subcortical white matter in the primary sensory and motor regions ("2"), caudate/putamen ("3"), pons in the vicinity of the reticular nuclei ("4"), lateral pontomedullary junction ("5"), medial pontomedullary junction ("6"), and white matter adjacent to the superior colliculus ("7"). (B) Two-dimensional displays of these clusters overlaid on a standard mouse MRI template. The color scale represents t values threshold at 3.9 corresponding to P < 0.001 (uncorrected). Individual cluster values for the mutant and for the control groups are represented by box-and-whisker plots. All group differences were highly significant (P < 0.0001). | ||||
| Copyright | This image is from Ulug AM, Proc Natl Acad Sci U S A 2011 Apr 19;108(16):6638-43. Copyright 2011 National Academy of Sciences, U.S.A. J:171370 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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