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Caption Craniofacial anomalies in Ptprstm1Mtr/Ptprstm1Mtr Ptprftm1Wjh/Ptprftm1Wjh (Ptprs-/-;PtprfdeltaP/deltaP) double-mutant embryos. (A-C) Gross morphological appearance of control (A) and double mutant (B and C) embryos at E18.5. Note the presence of micrognathia (arrow), exencephaly (arrowhead) and open eyelid (open arrowhead) in mutant embryos. (D and E) Coronal sections of the face region of control (D) and mutant (E) embryos stained by H&E. The tongue and palate of control embryos were readily distinguishable, whereas mutant embryos showed smaller lower jaw (arrowhead) and an opened palate (open arrowhead) at an equivalent level of the head. (F-I) Coronal sections of the eye of control (F and H) and mutant (G and I) embryos stained by H&E. In contrast to the characteristic eye morphology observed in control embryos, mutant eyes sometimes showed a hyperplastic inner nuclear layer (single asterisk in G) and abnormal retrolental tissue (indicated by dotted line in I) filling the hyaloid cavity. (H and I) High-magnification views of the boxes in F and G. (I) In mutant embryos, neuroretinal lamination was disorganized (arrows). Note the presence of pigmented cells (white arrowheads), the hyaloid artery within the retrolental tissue (double asterisk), and the lens degradation (black arrowhead). Scale bars: 1 mm (A-G) and 10 um (H and I). ONL, outer nuclear layer; INL, inner nuclear layer.
Copyright This image is from Uetani N, J Clin Invest 2009 Apr;119(4):924-35 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:149756
Symbol Name
Ptprftm1Wjh protein tyrosine phosphatase, receptor type, F; targeted mutation 1, Wiljan JAJ Hendriks
Ptprstm1Mtr protein tyrosine phosphatase, receptor type, S; targeted mutation 1, Michel L Tremblay
Allelic Composition Genetic Background
B6.Cg-Ptprftm1Wjh Ptprstm1Mtr

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