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| Caption | Hepatic steatosis in C3tm1Crr/C3tm1Crr (C3-/-) and C5ar2tm1Gdy/C5ar2tm1Gdy (C5L2-/-) mice following partial hepatectomy (PHx). (A) Representative H&E-stained sections showing C3 and C5L2 deficiency is associated with a marked increase in necrosis with hepatic micro- and macrovesicular steatosis, whereas wild-type (WT) mice and C3-/- mice treated with 15 ug acylation-stimulating protein (ASP) exhibit much less apparent steatosis. (B) Representative oil red O-stained sections. Both homozygous mutant mice have increased micro- and macrovesicular steatosis compared with WT mice and C3-/- mice treated with 15 ug ASP. Original magnification in A and B, 400. (C) Quantification of hepatic triglyceride accumulation. ##P < 0.01 versus WT groups; **P < 0.01 versus C3-/- groups. Results expressed as mean SD; n = 4-6. | ||||||
| Copyright | This image is from He S, J Clin Invest 2009 Aug;119(8):2304-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152533 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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