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Phenotype Image Detail
Image
Caption Complement deficiency protects against hepatic injury following ischemia/reperfusion. Determinations were performed using liver after 30 minutes ischemia and 6 hours reperfusion in mice treated with nomral saline (NS) or CR2-Crry. Representative H&E-stained liver sections of C3tm1Crr/C3tm1Crr (C3-/-) and wild-type (Wt) mice 6 hours after reperfusion, with the arrow-outlined area showing widespread hepatic necrosis in Wt mice. Original magnification, x100.
Copyright This image is from He S, J Clin Invest 2009 Aug;119(8):2304-16 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152533
Associated
Alleles
Symbol Name
C3tm1Crr complement component 3; targeted mutation 1, Michael C Carroll
Associated
Genotypes
Allelic Composition Genetic Background
C3tm1Crr/C3tm1Crr involves: 129S4/SvJae * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory