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Phenotype Image Detail
Image
Caption Homozygous deletion of Trim33 (Tif1gamma) cooperates with activated KrasG12D mutation to induce cystic tumors of the pancreas in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 (Pdx1-cre;LSL-KrasG12D;Tif1gammalox/lox) mice. Homozgyous deletion of Cdkn2a cooperates with activated KrasG12D mutation to induce solid tumors in Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;LSL-KrasG12D;Ink4A/Arflox/lox). Magnetic Resonance Imaging (MRI) (A-C). Positron Emission Tomography (PET) (D-F). Gross anatomy of the pancreas after dissection (G-I). Hematoxylin Phloxine Saffron (HPS) staining of pancreas sections (J-L). Acinar tissue (stars), scattered endocrine islets (arrow) and exocrine ducts (arrowhead). When notified, pancreas is circled in red dashed lines. Pdx1-cre;LSL-KrasG12D;Tif1gammalox/lox mice used in this experiment were 154 days old and representative of the 4 mice we analyzed at the age of 18-27 weeks.
Copyright This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781
Associated
Alleles
Symbol Name
Cdkn2atm4Rdp cyclin dependent kinase inhibitor 2A; targeted mutation 4, Ronald DePinho
Krastm4Tyj Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Tg(Pdx1-cre)89.1Dam transgene insertion 89.1, Douglas A Melton
Trim33tm1Los tripartite motif-containing 33; targeted mutation 1, Regine Losson
Associated
Genotypes
Allelic Composition Genetic Background
Krastm4Tyj/Krastm4Tyj
Trim33tm1Los/Trim33tm1Los
Tg(Pdx1-cre)89.1Dam/0
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * DBA/2

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory