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Phenotype Image Detail
Image
Caption Ablation of Spp1 correlates with reductions in diaphragm and cardiac fibrosis. Micrographs show representative trichrome staining of diaphragms from Dmdmdx/Dmdmdx or Dmdmdx/Y (left panels) and Dmdmdx/Dmdmdx Spp1tm1Blh/Spp1tm1Blh or Dmdmdx/Y Spp1tm1Blh/Spp1tm1Blh (DMM, right panels) animals. The top 2 panels are of 6-month-old mice, whereas bottom 2 panels are of 7-month-old mice. Areas of blue staining indicate proliferation of ECM (i.e., fibrosis), and areas of red staining indicate muscle tissue. Original magnification, x20.
Copyright This image is from Vetrone SA, J Clin Invest 2009 Jun;119(6):1583-94 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:150572
Associated
Alleles
Symbol Name
Dmdmdx dystrophin, muscular dystrophy; X linked muscular dystrophy
Spp1tm1Blh secreted phosphoprotein 1; targeted mutation 1, Brigid L Hogan
Associated
Genotypes
Allelic Composition Genetic Background
Dmdmdx/Y
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Dmdmdx/Dmdmdx
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory