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| Caption | Ablation of Spp1 correlates with reductions in diaphragm and cardiac fibrosis. Micrographs show representative trichrome staining of diaphragms from Dmdmdx/Dmdmdx or Dmdmdx/Y (left panels) and Dmdmdx/Dmdmdx Spp1tm1Blh/Spp1tm1Blh or Dmdmdx/Y Spp1tm1Blh/Spp1tm1Blh (DMM, right panels) animals. The top 2 panels are of 6-month-old mice, whereas bottom 2 panels are of 7-month-old mice. Areas of blue staining indicate proliferation of ECM (i.e., fibrosis), and areas of red staining indicate muscle tissue. Original magnification, x20. | ||||||
| Copyright | This image is from Vetrone SA, J Clin Invest 2009 Jun;119(6):1583-94 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:150572 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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