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Phenotype Image Detail
Image
Caption Skeletal staining illustrating noncomplementation between Ptch1dl (DL) and Ptch1tm1Mps (Ptch1-LacZ) mutant alleles. E18.5 Ptch1dl heterozygotes (a, c, e, g, i, k) and Ptch1dl/Ptch1tm1Mps mutants (b, d, f, h, j, l). Lateral views of skulls (a, b) with red arrow showing abnormal flexure at skull and nasal juncture. Dorsal view of skulls (c, d). Black arrow in (d) illustrates lack of lambdoid suture. Ventral view of skull with mandibles removed (e, f) with the absence of the presphenoid bone and the under-development of the palatal shelves (red asterisk), and the aberrant morphology of the alisphenoid bone (white arrow) marked in the Ptch1dl/Ptch1tm1Mps mutants. (g, h) Lateral view of dentary bones. (i, j) Ribcage in ventral view. (k, l) forelimbs. Key: A, anterior; ap, angular process; Bo, basioccipital; Bs, basisphenoid; cdp, condylar process; crp, coronoid process; Fr, frontal bone; Hy, hyoid; Ip, interparietal bone; M, manubrium; Mx, palatine process of the maxilla; N, nasal bone; P, posterior; Pl, palatine; Pr, parietal bone; Ps, presphenoid; Px, premaxilla; X, xiphoid process.
Copyright This image is from Feng W, Genesis 2013 Oct;51(10):677-89, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:204468
Associated
Alleles
Symbol Name
Ptch1dl patched 1; dogface-like
Ptch1tm1Mps patched 1; targeted mutation 1, Matthew P Scott
Associated
Genotypes
Allelic Composition Genetic Background
Ptch1dl/Ptch1tm1Mps involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory