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Phenotype Image Detail
Image
Caption Histological features of anal squamous cell carcinoma (ASCC) in Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice. Representative saggital sections of ASCC tumors showing differentiated epithelial cells that grew as solid sheets or nests. Invasion of ASCC into surrounding tissue (B) and origination of ASCC (C). Coronal section of ASCC showing ASCC tumor in squamous epithelial (D) but not in columnar epithelial cells (E, F). (Hematoxylin and eosin staining).
Copyright This image is from Sun ZJ, PLoS One 2013;8(10):e74888, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:209026
Associated
Alleles
Symbol Name
Ptentm1Hwu phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Tgfbr1tm1.1Karl transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson
Associated
Genotypes
Allelic Composition Genetic Background
Ptentm1Hwu/Ptentm1Hwu
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Tg(KRT14-cre/ERT)20Efu/0
involves: 129 * 129S4/SvJae * C57BL/6 * CD-1 * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory