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Phenotype Image Detail
Image
Caption Embryos from Ptbp1tm1Msol heterozygous parents fall into 2 size categories. Hematoxylin and eosin stained decidual sections of 2 litters were analysed for surface area and structural organisation. Embryos were grouped according to their developmental stage (left) with the furthest developed having reached neural plate stage but most embryos being at the primitive streak stage. The surface area of the embryos in the middle section was measured with the Fiji image software and ranked according to size, which turned out as equivalent to stage (right). Presumedknockouts (red) were significantly smaller than wild-type or heterozygous controls and present in a roughly Mendelian ratio of 3:10 (ratio 0.3 vs. the expected 0.25). The size of the small embryos might have even been overestimated since it was harder to recognise the embryo in those implantations. We also encountered 2 decidua with no visible embryonic structures.
Copyright This image is from Suckale J, PLoS One 2011;6(2):e16992, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:223915
Associated
Alleles
Symbol Name
Ptbp1tm1Msol polypyrimidine tract binding protein 1; targeted mutation 1, Michele Solimena
Associated
Genotypes
Allelic Composition Genetic Background
Ptbp1tm1Msol/Ptbp1tm1Msol B6J.129-Ptbp1tm1Msol

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory