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| Caption | Neuropathologic processes of Prnptm3Lnq/Prnptm3Lnq (CJD - Creutzfeldt-Jakob Disease) mice. Sections (5 um thick) from paraffin-embedded hippocampal (A-D) or cerebellar (E and F) areas stained with H&E (A and B) or with PrP antibody 3F4 following proteinase K digestion (C-F). Prnptm3Lnq/Prnptm3Lnq sections are shown (A,C, and E) with corresponding Prnptm2Lnq/Prnptm2Lnq (FFI) sections (B, D, and F). Prnptm3Lnq/Prnptm3Lnq (CJD) mice have prominent spongiform degeneration in the hippocampal CA1 region, specifically in the synapse-rich area of the molecular layer. Prnptm2Lnq/Prnptm2Lnq (FFI) brains do not. (Scale bars: 0.05 mm). | ||||
| Copyright | This image is from Jackson WS, Proc Natl Acad Sci U S A 2013 Sep 3;110(36):14759-64. Copyright 2013 National Academy of Sciences, U.S.A. J:200974 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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