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Phenotype Image Detail
Image
Caption Compared with control Gnl3tm2.1Rylt/Gnl3tm2.1Rylt (Nsf/f) embryos, Gnl3tm2.1Rylt/Gnl3tm2.1Rylt Tg(Nes-cre)1Kln/0 (neNScko) embryos begin to show a decreased cellularity in the telencephalic (T), diencephalic (D), mesencephalic (M), and rhombencephalic (R) neuroepithelium at E12.5. Squares indicate regions shown in G. At E14.5 (D) and E16.5 (E), mutant (neNScko) embryos exhibit severe brain defects throughout the neural axis. Ce, cerebellar primordium. (F) At E12.5, the forebrains of mutant embryos contain much less sphere-forming neural stem cells (NSCs) than that of control (NSf/f) embryos. (G) A notable phenotype is the increase of gamma-H2AX+ cells in the ventricular zone of the E12.5 neuroepithelium. The region shown here is close to the midbrain roof. (Scale bars: 500 um in C, 1 mm in D and E, and 100 um in F and G.) Bar graphs, mean +/- SEM; *P < 0.01; **P < 0.001; ***P < 0.0001.
Copyright This image is from Meng L, Proc Natl Acad Sci U S A 2013 Jul 9;110(28):11415-20. Copyright 2013 National Academy of Sciences, U.S.A. J:198698
Associated
Alleles
Symbol Name
Gnl3tm2.1Rylt guanine nucleotide binding protein-like 3 (nucleolar); targeted mutation 2.1, Robert Y L Tsai
Tg(Nes-cre)1Kln transgene insertion 1, Rudiger Klein
Associated
Genotypes
Allelic Composition Genetic Background
Gnl3tm2.1Rylt/Gnl3tm2.1Rylt
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * CBA

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory