Phenotype Image Detail

Image

Caption

Mesenchymal removal of Smo in the developing intestine. B and C, H&E staining of the intestine of control and Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Smo^tm2Amc/Smo^tm2Amc (Nkx3.2^Cre;Smo^C/C) embryos at E18.5. White dashed lines delineate the boundary of gut epithelium and mesenchyme. D-K, defects in mesenchymal growth and patterning in mutant embryos at E18.5. Shown is immunohistochemical staining of Ki67 (D and H), cleaved caspase 3 (E and I), SMA (F and J), and Beta-tubulin (G and K) in the intestine of control and mutant embryos.

This image is from Huang H, J Biol Chem 2013 Jun 14;288(24):17589-96 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199664

Associated
Alleles

Symbol	Name
Nkx3-2^tm1(cre)Wez	NK3 homeobox 2; targeted mutation 1, Warren E Zimmer
Smo^tm2Amc	smoothened, frizzled class receptor; targeted mutation 2, Andrew P McMahon

Associated
Genotypes

Allelic Composition	Genetic Background
Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23