Phenotype Image Detail

Image

Caption

Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) pups exhibit focal desquamation and abnormal epidermal histology. (A and B), Wild-type (Sgpp1^+/+) and Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg} (Sgpp1^-/-) mice at 0.5 days (A) and 4 days after birth (B). The arrows in B indicate sites of desquamation. C-E, histology of mutant mouse skin. Paraffin sections of back skin from 2-day-old wild-type (C) and mutant (D and E) mice were stained with H&E. E represents a region of back skin undergoing peeling of the stratum corneum (marked by arrows) Bar, 200 um. SC, stratum corneum; SL, subcorneal layer.

This image is from Allende ML, J Biol Chem 2013 Jun 21;288(25):18381-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:199597

Associated
Alleles

Symbol	Name
Sgpp1^{tm1(KOMP)Vlcg}	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene
Sgpp1^{tm1(KOMP)Vlcg}	sphingosine-1-phosphate phosphatase 1; targeted mutation 1, Velocigene

Associated
Genotypes

Allelic Composition	Genetic Background
Sgpp1^{tm1(KOMP)Vlcg}/Sgpp1^{tm1(KOMP)Vlcg}	involves: C57BL/6NTac

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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