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| Caption | Reduced tumor growth in Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre/ERT2)CIVE23Mlia/0 (EC-iDKO) and Epn1tm1.1Wami/Epn1tm1.1Wami Epn2tm1Ocr/Epn2tm1Ocr Tg(Cdh5-cre)7Mlia/0 (EC-DKO) mice. (A and B) Representative wild-type (WT) or EC-iDKO mice bearing Lewis Lung carcinoma (LLC) tumors (A) or Melanoma tumors (B) at 18 days post inoculation of tumor cells. Dotted lines indicate tumors. (C) Representative WT or EC-DKO mice bearing LLC tumors at 18 days post inoculation of tumor cells. (D) Representative mouse brain T2-weighted images for WT and EC-iDKO gliomas, 24 days following GL261 cells injection.Images were acquired with a slice thickness of 0.5 mm and a FOV of 2 x 2 cm2, for an approximate in-plane resolution of 80 um. Dashed yellow lines mark tumors. (E) Longitudinally cut colon and rectum regions of WT and EC-iDKO mice challenged with azoxymethane (AOM) and dextran sodium sulphate (DSS). Mice were sacrificed after 18 weeks following treatment. | ||||||||||
| Copyright | This image is from Pasula S, J Clin Invest 2012 Dec 3;122(12):4424-38 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193966 | ||||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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