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| Caption | Analysis of limb and diaphragm muscles of the Col6a3tm1Chu/Col6a3tm1Chu (hm/hm) mouse mutant. A, cryosections of gastrocnemius (Gas), quadriceps (Qua), and diaphragm (Dia) muscles of wild-type (+/+) and homozygous mutant mice (hm/hm) were stained with hematoxylin and eosin. Centrally localized nuclei (arrows) are abundant in the homozygous mutant muscles but barely detectable in the wild-type controls. An increase in the interstitial connective tissue between muscle fibers is evident in the homozygous mutant mice compared with the wild-type control. Magnification bars, 50 um. D, increased immunoreactivity of type I collagen in homozygous mutant muscle. Cryosections of quadriceps muscles from 6-month-old wild-type and mutantmice were immunostained with affinity-purified antibody against type I collagen. A representative image is shown. | ||||
| Copyright | This image is from Pan TC, J Biol Chem 2013 May 17;288(20):14320-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198581 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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