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| Caption | Abnormal gross appearance and histology of Fgfr2tm2Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 (+/P253R) mice. A-D) Alizarin red S and Alcian blue staining of the skull shows domed-shaped skulls with shortened anterioposterior length, short nasal snouts and upper jaw in mutant; I,J) Alizarin red S and Alcian blue staining of the chest shows abnormal bony fusion of sternum (white arrow) in mutant. E-H) Palate abnormalities: (E, F) Superior view shows a defect located at the junction between the primary and secondary palate in mutant (arrow). (G, H) Histology shows incomplete fusion in mutant (arrows). (K, L) Abnormal chondro-osseous transition at the physis in mutant (brackets). Panels A, C, E, G, I, and K are from littermate controls. Panels B, D, F, H, J, and L are the corresponding organs and tissues in mutant mice. (Scale bars: I-P = 50 um). | ||||||
| Copyright | This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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