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Phenotype Image Detail
Image
Caption Cerebellar abnormalities in Braftm2Urr/Braftm2Urr Tg(Nes-cre)1Kln/0 and Braftm2.1Urr/Braftm2.1Urr Tg(Nes-cre)1Kln/0 (cKO) mice. (A, A') Representative sagittal sections of P21 cerebellum stained with haematoxylin and eosin (HE) are shown in the upper panel. (B, B') HE-stained pictures display the reduced size of lobe X with disorganized glomeruli. (C, C') Calbindin staining was used to visualize the elongated primarydendrite and reduced and irregular arborization of Purkinje neurons in the molecular layer. Scale bars; 25 mm or as indicated.
Copyright This image is from Pfeiffer V, PLoS One 2013;8(3):e58259, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199842
Associated
Alleles
Symbol Name
Braftm2.1Urr Braf transforming gene; targeted mutation 2.1, Urr R Rapp
Braftm2Urr Braf transforming gene; targeted mutation 2, Urr R Rapp
Tg(Nes-cre)1Kln transgene insertion 1, Rudiger Klein
Associated
Genotypes
Allelic Composition Genetic Background
Braftm2.1Urr/Braftm2.1Urr
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL
Braftm2Urr/Braftm2Urr
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory