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Caption Absence of Pten in the mesenchyme does not affect lung morphogenesis, but leads to increased mesenchymal cell proliferation. (A-D) Histological analysis of E18.5 lungs. Ptentm1Hwu/Ptentm1Hwu (Ptenfl/fl) and Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ (Ptenfl/fl;Dermo-Cre) lungs were hematoxylin and eosin (H&E) stained. Representative control and mutant sections are shown. No macroscopic differences were detected between the control and mutant embryos except for increased cell density (D versus C). Scale bars: 100 um (A and B); 50 um (lower magnification), 20 um (higher magnification) (C and D). (E and F) Increased cell proliferation in conditional mutant mice compared with controls. IF for E-CAD and PH3, showing increased proliferation in conditional mutant mesenchyme (F) compared with Ptentm1Hwu/Ptentm1Hwu (E). Scale bars: 50 um.
Copyright This image is from Tiozzo C, J Clin Invest 2012 Nov 1;122(11):3862-72 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:192736
Symbol Name
Ptentm1Hwu phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Twist2tm1.1(cre)Dor twist basic helix-loop-helix transcription factor 2; targeted mutation 1.1, David M Ornitz
Allelic Composition Genetic Background
B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu

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