Phenotype Image Detail

Image

Caption

Aortic root atherosclerosis. A) Representative trichrome-stained images of lesions in the aortic root and lesion area measurements. Left image: Apoe^tm1Unc/Apoe^tm1Unc (11betaHSD1^+/+/ApoE^-/-) aortic root. Right image: Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex (11betaHSD1^-/-/ApoE^-/-) aortic root. Asterisks denote regions of acellular necrotic debris. Plot:Lesion area measurements from trichrome-stained images in Apoe^tm1Unc/Apoe^tm1Unc (n = 10) and Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex (n = 9) male mice. B) Intraplaque necrotic areas. Left image: Apoe^tm1Unc/Apoe^tm1Unc aortic root plaque. Right image: Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex aortic root plaque. Asterisks denote necrotic areas within lesions. Acellularity and features of crystalline clefts were used to demarcate necrotic regions. Plot: Necrotic core area measurements from trichrome-stained images in Apoe^tm1Unc/Apoe^tm1Unc (n = 10) and Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex (n = 9) male mice. C) Macrophage staining via CD68 immunohistochemistry. Left image: Apoe^tm1Unc/Apoe^tm1Unc aortic root. Right image: Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex aortic root. Arrows denote CD68 positive staining. Plot: CD68 positive stained area measurements in Apoe^tm1Unc/Apoe^tm1Unc (n - 10) and Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex (n = 9) male mice. Significance vs. control: *p<= 0.05. Data are pooled from two independently run in vivo studies.

This image is from Garcia RA, PLoS One 2013;8(2):e53192, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199430

Associated
Alleles

Symbol	Name
Apoe^tm1Unc	apolipoprotein E; targeted mutation 1, University of North Carolina
Hsd11b1^tm1Lex	hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Lexicon Genetics

Associated
Genotypes

Allelic Composition	Genetic Background
Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex	B6.129-Hsd11b1^tm1Lex Apoe^tm1Unc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23