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| Caption | Histology of homozygous Pkd1tm1.1Pcha (Pkd1RC/RC) animals mimics typical Autosomal Dominant Polycystic Kidney Disease (ADPKD). (A) Representative Masson Trichrome histology sections of Pkd1tm1.1Pcha/Pkd1tm1.1Pcha (Pkd1RC/RC) and wild-type (WT) mouse kidneys at 1 to 12 months show that cysts developed progressively with age. At later time points, an increased level of fibrosis was noted (12 months). Scale bars: 1 mm (kidney cross-section, WT, and Pkd1RC/RC); 250 um (Pkd1RC/RC magnified region [images in second column]); 200 um (WT magnified region [insets]). (B) Masson Trichrome histology sections of 12-month-old Pkd1RC/RC and WT livers (no significant difference between percentage of liver weight [LW] per body weight [%LW/BW] of WT animals and homozygotes was noted). Four out of five homozygous animals showed ductal plate malformations, including microhamartomas of varying severity. These cystic lesions are progenitors of the liver cysts often found in patients with ADPKD. Scale bars: 100 um. | ||||
| Copyright | This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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