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Phenotype Image Detail
Image
Caption Rib fusion phenotype of Gnai3tm1Lbi/Gnai3tm1Lbi (Gnai3-/-) mice is enhanced by loss of Gnai2 in cartilage. (B) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai2tm2.1Lbi/Gnai2tm2.1Lbi (Gnai3-/- Gnai2flx/flx) neonate with one rib fusion (black arrowhead). (C) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai2tm2.1Lbi/Gnai2tm2.1Lbi Tg(Myog-cre)1Eno/0 (Gnai3-/- Gnai2flx/flx Myog-cre) neonate with one rib fusion (black arrowhead). (D) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai2tm2.1Lbi/Gnai2tm2.1Lbi Sox9tm3(cre)Crm/Sox9+ (Gnai3-/- Gnai2flx/flx Sox9cre) neonate with 10 rib fusions.
Copyright This image is from Plummer NW, Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21366-71. Copyright 2012 National Academy of Sciences, U.S.A. J:193170
Associated
Alleles
Symbol Name
Gnai2tm2.1Lbi G protein subunit alpha i2; targeted mutation 2.1, Lutz Birnbaumer
Gnai3tm1Lbi G protein subunit alpha i3; targeted mutation 1, Lutz Birnbaumer
Sox9tm3(cre)Crm SRY (sex determining region Y)-box 9; targeted mutation 3, Benoit de Crombrugghe
Tg(Myog-cre)1Eno transgene insertion 1, Eric N Olson
Associated
Genotypes
Allelic Composition Genetic Background
Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+ 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Gnai2tm2.1Lbi/Gnai2tm2.1Lbi
Gnai3tm1Lbi/Gnai3tm1Lbi
Tg(Myog-cre)1Eno/0 		involves: 129S/SvEv * C57BL/6
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory