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Phenotype Image Detail
Image
Caption A, representative image of a heterozygous Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2+ (+/gt) pup and a homozygous Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu (gt/gt) pup just after birth (P0). Homozygous pups died at birth, due to a failure to initiate respiration (their lungs remained uninflated), and showed a distinctive hunched posture. Hunched posture was already evident in E18.5 embryos which showed signs of paralysis. Heterozygous pups and embryos were indistinguishable from wild-types (+/+) in this respect. B, representative bladders dissected from fixed wild-type, heterozygous and homozygous E18.5 embryos. Homozygous E18.5 embryos and P0 pups have massively swollen bladders. In contrast, heterozygous E18.5 embryos and P0 pups have normal bladders.
Copyright This image is from Hicks AN, PLoS One 2012;7(10):e47869, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192196
Associated
Alleles
Symbol Name
Nmnat2Gt(EUCE0262a08)Hmgu nicotinamide nucleotide adenylyltransferase 2; gene trap EUCE0262a08, Helmholtz Zentrum Muenchen GmbH
Associated
Genotypes
Allelic Composition Genetic Background
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu involves: 129P2/OlaHsd * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory