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Phenotype Image Detail
Image
Caption Ablation of Cd74 restores morphological changes in Sppl2atm1Basc/Sppl2atm1Basc B cells. (A) Representative cross sections of splenic IgM+ wild-type (wt), Sppl2atm1Basc/Sppl2atm1Basc (SPPL2a-/-), Cd74tm1Liz/Cd74tm1Liz (CD74-/-), and Sppl2atm1Basc/Sppl2atm1Basc Cd74tm1Liz/Cd74tm1Liz (SPPL2a-/- CD74-/-) B cells. Sppl2atm1Basc/Sppl2atm1Basc Cd74tm1Liz/Cd74tm1Liz splenic IgM+ B cells are indistinguishable from wild-type and Cd74tm1Liz/Cd74tm1Liz cells, with similiar numbers of vacuoles per cell. Bars, 1 um.
Copyright This image is from Schneppenheim J, J Exp Med 2013 Jan 14;210(1):41-58, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:194664
Associated
Alleles
Symbol Name
Cd74tm1Liz CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Elizabeth K Bikoff
Sppl2atm1Basc signal peptide peptidase like 2A; targeted mutation 1, Bernd Schroder
Associated
Genotypes
Allelic Composition Genetic Background
Sppl2atm1Basc/Sppl2atm1Basc involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Cd74tm1Liz/Cd74tm1Liz
Sppl2atm1Basc/Sppl2atm1Basc
B6.129-Sppl2atm1Basc Cd74tm1Liz

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory