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| Caption | Effects of genetic depletion of 11-cis-retinal production or absence of rod phototransduction on retinal degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal (KK) mice. (A) Plastic sections of retinas crossing the optic nerve head of 2-month-old Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal (KKLrat-/-) mice. Sections were stained with toluidine blue (upper panels). Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal retina showed increased number of rows of photoreceptor cell nuclei as compared with age-matched KK retina. This finding is consistent with the increased thickness of the outer nuclear layer (ONL) in Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal retina shown in the corresponding spectral domain optical coherence tomography (SD-OCT) images (lower panels). (C) SD-OCT images of retinas crossing the optic nerve head from 1-month-old Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma (KKGnat1-/-) mice. Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma retina displayed decreased thickness of ONL relative to an age-matched Rhotm2.1Kpal/Rhotm2.1Kpal (KK) retina. | ||||||||
| Copyright | This image is from Zhang N, J Clin Invest 2013 Jan 2;123(1):121-37 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194158 | ||||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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