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Phenotype Image Detail
Image
Caption Effects of genetic depletion of 11-cis-retinal production or absence of rod phototransduction on retinal degeneration in Rhotm2.1Kpal/Rhotm2.1Kpal (KK) mice. (A) Plastic sections of retinas crossing the optic nerve head of 2-month-old Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal (KKLrat-/-) mice. Sections were stained with toluidine blue (upper panels). Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal retina showed increased number of rows of photoreceptor cell nuclei as compared with age-matched KK retina. This finding is consistent with the increased thickness of the outer nuclear layer (ONL) in Rhotm2.1Kpal/Rhotm2.1Kpal Lrattm1Kpal/Lrattm1Kpal retina shown in the corresponding spectral domain optical coherence tomography (SD-OCT) images (lower panels). (C) SD-OCT images of retinas crossing the optic nerve head from 1-month-old Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma (KKGnat1-/-) mice. Rhotm2.1Kpal/Rhotm2.1Kpal Gnat1tm1Clma/Gnat1tm1Clma retina displayed decreased thickness of ONL relative to an age-matched Rhotm2.1Kpal/Rhotm2.1Kpal (KK) retina.
Copyright This image is from Zhang N, J Clin Invest 2013 Jan 2;123(1):121-37 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194158
Associated
Alleles
Symbol Name
Gnat1tm1Clma guanine nucleotide binding protein, alpha transducing 1; targeted mutation 1, C L Makino
Lrattm1Kpal lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1, Krzysztof Palczewski
Rhotm2.1Kpal rhodopsin; targeted mutation 2.1, Krzysztof Palczewski
Associated
Genotypes
Allelic Composition Genetic Background
Lrattm1Kpal/Lrattm1Kpal
Rhotm2.1Kpal/Rhotm2.1Kpal
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Gnat1tm1Clma/Gnat1tm1Clma
Rhotm2.1Kpal/Rhotm2.1Kpal
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory