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Phenotype Image Detail
Image
Caption Purkinje cells (PCs) degenerate over time in Afg3l2tm1Arte/Afg3l2tm1Arte Tg(Pcp2-cre)2Mpin/0 (Afg312PC-KO) mice. Vibratome sections of the cerebellum were collected at various time points from Afg3l2tm1Arte/Afg3l2tm1Arte (Afg312fl/fl) and Afg3l2tm1Arte/Afg3l2tm1Arte Tg(Pcp2-cre)2Mpin/0 mice and stained for (A-D) calbindin to show progressive PC loss, (E-H) IBA1 to detect resting and activated microglia; and (I-L) glial fibrillary protein (GFAP) to mark reactive astrocytes. Scale bar: 100 um.
Copyright This image is from Almajan ER, J Clin Invest 2012 Nov 1;122(11):4048-58 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193564
Associated
Alleles
Symbol Name
Afg3l2tm1Arte AFG3-like AAA ATPase 2; targeted mutation 1, TaconicArtemis
Tg(Pcp2-cre)2Mpin transgene insertion 2, Max-Planck-Institute of Neurobiology
Associated
Genotypes
Allelic Composition Genetic Background
Afg3l2tm1Arte/Afg3l2tm1Arte
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory