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| Caption | Ears of Il1rl2tm1Hblu/Il1rl2tm1Hblu (Il36r-/-), Il36rntm1Kopf/Il36rntm1Kopf (Il36rn-/-) and wild-type (WT) mice (n >= 4 per group) were topically treated with an IMQ-containing cream (Aldara, MEDA Pharma) for 7 consecutive days. (B) At day 7, photographs were taken from whole ears or (C) H&E-stained ear sections representing the thickest epidermal region of each ear from individual mice representative of indicated groups. Epidermis (e), dermis (d), and hair follicle (f) are indicated. Data are representative of 4 experiments. Il1rl2tm1Hblu/Il1rl2tm1Hblu ears are protected from IMQ-induced psoriasis while Il36rntm1Kopf/Il36rntm1Kopf ears show increased severity of psoriasiform dermatitis compared to wild-type mice. Scale bar: 100 um. | ||||||
| Copyright | This image is from Tortola L, J Clin Invest 2012 Nov 1;122(11):3965-76 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193548 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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