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Phenotype Image Detail
Image
Caption Kdm6atm1.2Kaig/Kdm6atm1.2Kaig female embryos (UTX-/-) show defects in neural tube closure, cardiac development and hematopoiesis. Representative images of E10.5 and E11.5 embryos with indicated genotypes are shown. Abnormal or truncated posterior notochords were observed in mutant embryos. Red arrowheads indicate red blood cells in Aorta-Gonad Mesonephros, which were absent in mutant female embryos. Asterisks indicate cardiac effusion in mutant female embryos, represented by swollen pericardial sacs. White arrows point to the defects in neural tube closure.
Copyright This image is from Wang C, Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15324-9. Copyright 2012 National Academy of Sciences, U.S.A. J:190157
Associated
Alleles
Symbol Name
Kdm6atm1.2Kaig lysine (K)-specific demethylase 6A; targeted mutation 1.2, Kai Ge
Associated
Genotypes
Allelic Composition Genetic Background
Kdm6atm1.2Kaig/Kdm6atm1.2Kaig involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory