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Phenotype Image Detail
Caption Gross morphology and survival. (A) Untreated P21 mice: appearance of Atp6v0a4tm1.1Fekf/Atp6v0a4tm1.1Fekf, Atp6v0a4tm1.1Fekf/Atp6v0a4+, and wild-type (WT) respectively, Left to Right. (B) Weight: homozygous mutant animals had significantly lower body weight than WT or heterozygous animals. (C) Survival curve over 250 days (WT n = 25; heterozygotes, n = 43; homozygotes, n = 29); only two homozygous animals survived until the end of the census period. (D) Hydronephrotic kidney from a 9-month old homozygous animal (left) in comparison with an age-matched WT normal kidney (right). (Scale bar: 5 mm). Von Kossa staining in a P14 homozygote (E) and an 8-month old homozygote (F) animal, showing early and later medullary nephrocalcinosis. (Scale bars: 20 um.)
Copyright This image is from Norgett EE, Proc Natl Acad Sci U S A 2012 Aug 21;109(34):13775-80. Copyright 2012 National Academy of Sciences, U.S.A. J:188593
Symbol Name
Atp6v0a4tm1.1Fekf ATPase, H+ transporting, lysosomal V0 subunit A4; targeted mutation 1.1, Fiona E Karet Frankl
Allelic Composition Genetic Background
Atp6v0a4tm1.1Fekf/Atp6v0a4tm1.1Fekf involves: C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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