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| Caption | Fgfr2tm3Ewj/Fgfr2+ mice have cutis gyrata, acanthosis, skull synostosis, and other abnormalities. (A-D) Note skin furrows and hyperplasia in the mutant mice at P0 (A and B). With age, the skin phenotype becomes more obvious at P3 (C and D). (E-H) Surface reconstructions of HRCT images show midfacial hypoplasia of the mutant mice at P0. Note premature fusion of the coronal suture (E-H; black arrows), zygomaxillary suture (E-H; white arrows), and squamosal suture (E-H; red arrow) (I and J) Alizarian red S and Alcian blue staining of the chest show abnormal bony fusion of sternum in mutant at P0. (K and L) Gross observations reveal protruding and enlarged umbilical stump in mutant (arrow). A, C, E, G, I, and K are from littermate controls. B, D, F, H, J, and L show the corresponding organs and tissues in mutant mice. | ||||
| Copyright | This image is from Wang Y, J Clin Invest 2012 Jun 1;122(6):2153-64 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190491 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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