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| Caption | Conditional removal of Vcan in limb bud mesenchyme leads to limb deformities. A, x-ray visualization of 8-month-old mice (a and b) and gross observations of 1-week-old mouse hind limbs (c and d). Vcantm1.1Hwat/Vcantm1.1Hwat Tg(Prrx1-cre)1Cjt/0 (Prx1-Cre/Vcanflox/flox) mice (b and d) show distortion and shortening of digits, compared with Tg(Prrx1-cre)1Cjt/0 (Prx1-Cre/Vcan+/+; control) mice (a and c). B, histological analysis of newborn controls (a and c) and mutant (b and d) hind limbs by hematoxylin and eosin staining. Mutant digits display joint tilting (arrows in b) and clefting (arrowheads in b), formation of hypertrophic chondrocyte nodules in proximal phalanges, and delayed endochondral ossification (d).M, metatarsus; pp, proximal phalanges. Scale bars, 200 um (a and b) and 40 um (c and d). All of the histological sections (n >/= 5) of mutant digits show similar abnormalities. | ||||||
| Copyright | This image is from Choocheep K, J Biol Chem 2010 Jul 2;285(27):21114-25 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165936 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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