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Phenotype Image Detail
Image
Caption Livers of Cdk1tm2.1Kald/Cdk1tm2.1Kald Speer6-ps1Tg(Alb-cre)21Mgn/0 mice conatin fewer hepatocytes. (A) Liver sections from Cdk1tm2.1Kald/Cdk1tm2.1Kald Speer6-ps1Tg(Alb-cre)21Mgn/0 (Cdk1Liv-/-) and control (Cdk1FLOX) mice were stained with Feulgen to visualize their nuclei. Even though the overall liver size (B) is similar, mutant livers contained fewer hepatocytes with enlarged nuclei. (G) Mutants display a decreased hepatocyte density compared with controls and the difference is exacerbated by 96 hours after partial hepatectomy.
Copyright This image is from Diril MK, Proc Natl Acad Sci U S A 2012 Mar 6;109(10):3826-31. Copyright 2012 National Academy of Sciences, U.S.A. J:182141
Associated
Alleles
Symbol Name
Cdk1tm2.1Kald cyclin dependent kinase 1; targeted mutation 2.1, Philipp Kaldis
Speer6-ps1Tg(Alb-cre)21Mgn spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
Associated
Genotypes
Allelic Composition Genetic Background
Cdk1tm2.1Kald/Cdk1tm2.1Kald
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129 * C57BL/6 * DBA * SJL
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory