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Phenotype Image Detail
Image
Caption Increased cardiac neutrophil accumulation of Timp4tm1Vuo/Timp4tm1Vuo mice post-myocardial infarction is normalized by ablation of Mmp2. A, neutrophil staining of wild-type, Timp4tm1Vuo/Timp4tm1Vuo (Timp4-/-), and double knock-out Timp4tm1Vuo/Timp4tm1Vuo Mmp2tm1Ito/ Mmp2tm1Ito (Timp4-/-Mmp2-/-) cardiac tissue at 3 days following myocardial infarction. Scale bar, 50um.
Copyright This image is from Koskivirta I, J Biol Chem 2010 Aug 6;285(32):24487-93 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165901
Associated
Alleles
Symbol Name
Mmp2tm1Ito matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara
Timp4tm1Vuo tissue inhibitor of metalloproteinase 4; targeted mutation 1, Eero Vuorio
Associated
Genotypes
Allelic Composition Genetic Background
Timp4tm1Vuo/Timp4tm1Vuo involves: 129S7/SvEvBrd * C57BL/6
Mmp2tm1Ito/Mmp2tm1Ito
Timp4tm1Vuo/Timp4tm1Vuo
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory