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Phenotype Image Detail
Image
Caption Glycogen content in Gys2tm1.1Pro/Gys2tm1.1Pro (Conditional) and Gys2tm1.1Pro/Gys2tm1.1Pro Tg(Alb-cre)21Mgn/0 (LGSKO) mice. A and B, periodic acid-Schiff reagent staining of paraffin-embedded liver sections from random fed Gys2tm1.1Pro/Gys2tm1.1Pro (A) and Gys2tm1.1Pro/Gys2tm1.1Pro Tg(Alb-cre)21Mgn/0 (B) mice. The sections were counterstained for hematoxylin and eosin. All of the hepatocytes were stained pink in the liver sections from Conditional mice. Conversely, in LGSKO mouse sections only a small amount of cells (about 7%) were stained. The arrows point to those hepatocytes containing glycogen in the LGSKO mice sections. C and D, immunohistochemistry of paraffin-embedded liver sections of Conditional (C) and LGSKO (D) mice for CRE recombinase and counterstained with hematoxylin. Conditional mouse sections were negative for the staining, whereas LGSKO mouse sections were positively stained light brown in almost all the cells. However, some cells, marked by arrows, were not stained, indicating a lack of CRE recombinase protein.
Copyright This image is from Irimia JM, J Biol Chem 2010 Apr 23;285(17):12851-61 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:162043
Associated
Alleles
Symbol Name
Gys2tm1.1Pro glycogen synthase 2; targeted mutation 1.1, Peter J Roach
Tg(Alb-cre)21Mgn transgene insertion 21, Mark A Magnuson
Associated
Genotypes
Allelic Composition Genetic Background
Gys2tm1.1Pro/Gys2tm1.1Pro
Tg(Alb-cre)21Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory