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Phenotype Image Detail
Image
Caption Histological sections from central and peripheral retinas of 4-week-old Rpe65rd12/Rpe65rd12 (Rpe65rd12/rd12;Rho+/+) and Rpe65rd12/Rpe65rd12 RhoTvrm4/Rho+ (Rpe65rd12/rd12;RhoTvrm5/+) animals, n=3 mice. At 4 weeks of age, retinas of Rpe65rd12/Rpe65rd12 mice retained a full complement of photoreceptor nuclei. In comparison, Rpe65rd12/Rpe65rd12 RhoTvrm4/Rho+ mutants had only 2-3 rows of cell bodies remaining in the central ONL. The peripheral retina that also showed cell loss was better preserved than the central retina.
Copyright This image is from Budzynski E, J Biol Chem 2010 May 7;285(19):14521-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159523
Associated
Alleles
Symbol Name
RhoTvrm4 rhodopsin; translational research vision model 4
Rpe65rd12 retinal pigment epithelium 65; retinal degeneration 12
Associated
Genotypes
Allelic Composition Genetic Background
RhoTvrm4/Rho+
Rpe65rd12/Rpe65rd12
B6.Cg-Rpe65rd12 RhoTvrm4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory