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Phenotype Image Detail
Image
Caption Lens phenotypes. (A-D) Eyes were dilated and examined by slit lamp. (A) Wild-type (WT) mice (5 months old) had clear lenses (stage 0). (B) Heterozygous Cryaatm1Ady/Cryaa+ (WT/R49Cneo) mice (3 months old) had opacity in the posterior and nuclear regions of the lens (stage 2). (C) Homozygous Cryaatm1Ady/Cryaatm1Ady (R49Cneo/R49Cneo) mice (3 months old) had a nearly complete cataract (stage 3-4). (D) Cryaatm1Ady/Cryaatm1Ady mouse lenses showed a complete cataract at 5 months (stage 4). (E, F) Cataract in lens of a newborn homozygous Cryaatm1.1Ady/Cryaatm1.1Ady mouse with deletion of the neor gene by Cre-recombinase (R49C/R49C). Slit lamp image (E) shows a severe nuclear opacity at birth (stage 3). (F) Higher magnification of the lens shown in (E) shows the nuclear opacity covering ~70% of the lens.
Copyright This image is from Andley UP, BMC Ophthalmol 2009;9():4, an open-access article, licensee BioMed Central Ltd. J:157274
Associated
Alleles
Symbol Name
Cryaatm1.1Ady crystallin, alpha A; targeted mutation 1.1, Usha P Andley
Cryaatm1Ady crystallin, alpha A; targeted mutation 1, Usha P Andley
Associated
Genotypes
Allelic Composition Genetic Background
Cryaatm1.1Ady/Cryaatm1.1Ady involves: 129 * C57BL/6
Cryaatm1Ady/Cryaatm1Ady involves: 129
Cryaatm1Ady/Cryaa+ involves: 129

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory