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Phenotype Image Detail
Image
Caption Transcription-coupled nucleotide excision repair (TCR)-deficient mice show microglia and astrocyte activation in the white matter. A-F) Mac2-immunostaining of activated microglia in the medullary reticular formation of 25 week old wild-type (wt) and nucleotide excision repair (NER)-deficient mice showing the presence of Mac2-positive microglia cells in the reticular formation of Ercc8tm1Jhjh/Ercc8tm1Jhjh (Csa-/-) (B), Ercc6tm1Gvh/Ercc6tm1Gvh (Csb-/-) (C) and Ercc2tm3Jhjh/Ercc2tm3Jhjh (XpdXPCS) (E) mice, but not in Xpatm1Hvs/Xpatm1Hvs (Xpa-/-) or Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh (XpdTTD) mice.
Copyright This image is from Jaarsma D, PLoS Genet 2011 Dec;7(12):e1002405, an open-access article distributed under the terms of the Creative Commons Attribution License. J:179808
Associated
Alleles
Symbol Name
Ercc2tm2(ERCC2)Jhjh excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, Jan H J Hoeijmakers
Ercc2tm3Jhjh excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 3, Jan H J Hoeijmakers
Ercc6tm1Gvh excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Ercc8tm1Jhjh excision repaiross-complementing rodent repair deficiency, complementation group 8; targeted mutation 1, Jan H J Hoeijmakers
Xpatm1Hvs xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg
Associated
Genotypes
Allelic Composition Genetic Background
Ercc8tm1Jhjh/Ercc8tm1Jhjh involves: 129P2/OlaHsd * C57BL/6J
Ercc6tm1Gvh/Ercc6tm1Gvh involves: 129P2/OlaHsd * C57BL/6J
Ercc2tm3Jhjh/Ercc2tm3Jhjh involves: 129 * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory