Phenotype Image Detail

Image

Caption

Transcription-coupled nucleotide excision repair (TCR)-deficient mice show microglia and astrocyte activation in the white matter. A-F) Mac2-immunostaining of activated microglia in the medullary reticular formation of 25 week old wild-type (wt) and nucleotide excision repair (NER)-deficient mice showing the presence of Mac2-positive microglia cells in the reticular formation of Ercc8^tm1Jhjh/Ercc8^tm1Jhjh (Csa^-/-) (B), Ercc6^tm1Gvh/Ercc6^tm1Gvh (Csb^-/-) (C) and Ercc2^tm3Jhjh/Ercc2^tm3Jhjh (Xpd^XPCS) (E) mice, but not in Xpa^tm1Hvs/Xpa^tm1Hvs (Xpa^-/-) or Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} (Xpd^TTD) mice.

This image is from Jaarsma D, PLoS Genet 2011 Dec;7(12):e1002405, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179808

Associated
Alleles

Symbol	Name
Ercc2^{tm2(ERCC2)Jhjh}	excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, Jan H J Hoeijmakers
Ercc2^tm3Jhjh	excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 3, Jan H J Hoeijmakers
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Ercc8^tm1Jhjh	excision repaiross-complementing rodent repair deficiency, complementation group 8; targeted mutation 1, Jan H J Hoeijmakers
Xpa^tm1Hvs	xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg

Associated
Genotypes

Allelic Composition	Genetic Background
Ercc8^tm1Jhjh/Ercc8^tm1Jhjh	involves: 129P2/OlaHsd * C57BL/6J
Ercc6^tm1Gvh/Ercc6^tm1Gvh	involves: 129P2/OlaHsd * C57BL/6J
Ercc2^tm3Jhjh/Ercc2^tm3Jhjh	involves: 129 * C57BL/6J

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