Phenotype Image Detail

Image

Caption

E) Transmission electron microscopic examination of the ultrastructure of beta cells in pancreatic sections of Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn/0 (KO) mice and Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik (Flox) mice. Arrows indicate the ER distention in the beta cells of Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn/0 mice. Scale bar: 5 um. Significant differences were examined by Student's t test.

This image is from Wei FY, J Clin Invest 2011 Sep 1;121(9):3598-608 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:178248

Associated
Alleles

Symbol	Name
Cdkal1^tm1.1Tomik	CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa
Tg(Ins2-cre)25Mgn	transgene insertion 25, Mark A Magnuson

Associated
Genotypes

Allelic Composition	Genetic Background
Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn/0	B6.Cg-Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn

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