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Caption Rab25 deficiency promotes colon tumor formation and neoplasia in Smad3tm1Par/Smad3+ mice. (A) Smad3tm1Par/Smad3+ mice on a Rab25+/Rab25+ background (Smad3+/-Rab25+/+) did not show any adenomas in their colons. (B) Higher magnification of view of A shows normal colonic mucosa. (C) Swiss roll of Smad3tm1Par/Smad3+ Rab25tm1Jrgo/Rab25tm1Jrgo mouse (Smad3+/-Rab25-/-) colon. Note the numerous mucin-filled cysts. The image was captured using an Ario SL-50 imager. Areas of the image in which no tissue was present appear blank. (D) In a more aggressive proximal tumor, the cancerous lesions penetrated into the serosal wall with neoplastic atypical cystic glands filled with mucin. (E) The neoplastic colonic epithelium invaded into and through the submucosa, and the neoplastic glands invaded the muscle wall. (F) Rectal area of Smad3tm1Par/Smad3+ Rab25tm1Jrgo/Rab25tm1Jrgo mice. The neoplastic colonic epithelium penetrated muscle wall with atypical cystic glands filled with mucin. (G) Atypical cystic glands in epithelium and penetrating the muscle wall. (H) Vagina neoplasia. In vaginal epithelium, neoplastic squamous epithelial cells invaded the muscle layer. The vaginal lesions were not specific to ApcMin/Apc+ mice and were seen in Rab25-deficient mice on the 129 background. Scale bars: 1 mm.
Copyright This image is from Nam KT, J Clin Invest 2010 Mar;120(3):840-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158733
Symbol Name
Rab25tm1Jrgo RAB25, member RAS oncogene family; targeted mutation 1, James R Goldenring
Smad3tm1Par SMAD family member 3; targeted mutation 1, Luis F Parada
Allelic Composition Genetic Background
129-Rab25tm1Jrgo Smad3tm1Par

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