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| Caption | (A-D) E17.5 wild-type (+/+) (A) and Ptk7chz/Ptk7chz (chz/chz) embryos (B-D) in lateral (A-C) and dorsal view (D). Mutant embryos demonstrate the severe neural tube defect of craniorachischisis, where the neural tube is open from the midbrain/hindbrain boundary throughout the hindbrain and spinal cord, and the neural tissue is splayed on either side of the dorsal midline (D). Some mutants demonstrate failure to form closed eyelids (C) and a defect in ventral body wall development (likely omphalocele) with protrusion of the liver and guts (C). (E-L) Skeletal preparations of E17.5 wild-type (E, G, I) and mutant (F, H, J-L) fetuses stained with alcian blue for cartilage and alizarin red for bone. Dorsal views (E, F) demonstrate shortened and skewed body axis in mutants, with splayed vertebrae. Lateral views (G, H) reveal abnormal rib morphology, with fusions and bifurcations. Mutant limbs sometimes exhibit polydactyly with an extra digit postaxially (J, arrow) or preaxially (K, L arrows). | ||||
| Copyright | This image is from Paudyal A, BMC Dev Biol 2010;10():87, an open-access article, licensee BioMed Central Ltd. J:163834 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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