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Phenotype Image Detail
Image
Caption Whole-mount views of wild-type (Adam17+/+), Adam17tm1Imx/Adam17+, (Adam17deltaZn/+) and Adam17tm1Imx/Adam17tm1Imx (Adam17deltaZn/deltaZn) embryos at E11.5 (A), E14.5 (B) and E17.5 (C); embryos were unfixed, unstained. Homozygous mutant embryos exhibited hemorrhagic lesions compared with their wild-type and heterozygous littermates (see dotted boxes in B and C and higher magnification views in Figure 2). Hemorrhage was observed in E14.5 embryos and increased with gestational age. At later stage E17.5, the arrows denote edema.
Copyright This image is from Canault M, PLoS One 2010;5(10):e13433, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:166217
Associated
Alleles
Symbol Name
Adam17tm1Imx a disintegrin and metallopeptidase domain 17; targeted mutation 1, Immunex
Associated
Genotypes
Allelic Composition Genetic Background
Adam17tm1Imx/Adam17tm1Imx involves: 129 * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory