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| Caption | (A) The gene-targeting strategy for Tdrd5tm1Sait/Tdrd5tm1Sait (Tdrd5). The correct targeting generates ~7.0-kb bands when digested with EcoRV and probed with the 5' probe (green boxes). (B) Southern blot for the detection of the gene targeting. (C and D) Northern (C) or Western (D) blots of wild-type and mutant testes for mutant or TDRD5 expression. (C) A, probe A (5'); B, probe B (3') as shown in Fig. 1A. T5-1, -2, and -3, Tdrd5 isoforms 1, 2, and 3. (E) Testes of wild-type and mutant mice at 4- and 8-weeks of age. (F) The weight (the averages with SD; error bars) of wild-type and mutant testes (8 week old). (G) Histology of wild-type and mutant testes (top) and epididymis (bottom) stained by hematoxylin and eosin. (H) Alkaline phosphatase staining of wild-type and mutant male (left) and female (right) gonads at E12.5. Bars: (E) 2 mm; (G) 50 um; (H) 300 um. | ||||
| Copyright | This image is from Yabuta Y, J Cell Biol 2011 Mar 7;192(5):781-95, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:170319 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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