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| Caption | Reduced body size and x-ray analysis of P3h1tm1Dgen/P3h1tm1Dgen mice. P3h1tm1Dgen/P3h1tm1Dgen (-/-, A) mice typically appear smaller in size. Wild-types (+/+, B, black curve), heterozygotes (B, red curve), and homozygotes (B, blue curve) weights are plotted as a function of age with standard deviations shown. Homozygous mutant mice are considerably smaller already at 3 weeks of age and stay smaller through the lifetime. Full body x-rays (C) show pronounced curvature of the vertebrae and thinner skull of mutant mice as compared with age- and sex-matched wild-type mice. The difference is obvious at 3 months of age but progresses further in life as seen in the x-rays of 12 month old mice (C, right side). Hindlimb x-rays (D) of mutant mice show decreased bone mineral density as well as a foreshortening of the proximal bone relative to the distal bone in comparison with wild-type hindlimb. | ||||
| Copyright | This image is from Vranka JA, J Biol Chem 2010 May 28;285(22):17253-62 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:163884 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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