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Phenotype Image Detail
Image
Caption Pathological analysis of organ tissues of Il6tm1Poli/Il6tm1Poli and wild-type mice with candidiasis. (A and B) Periodic acid-Schiff stained sections from kidneys of Il6tm1Poli/Il6tm1Poli (A) or wild-type (B) mice at 5d after infection with virulent C. albicans. In mutant mice, an inflammatory lesion (arrows) is present with large necrotic areas and hyphal cells. (C,D) Medial sections from the stomach of wild-type (C) and mutant (D) mice inoculated intragastrically with C. albicans 2 weeks earlier. In mutant mice, note the presence of multiple, eruptive abscesses on the mucosal surface, and acanthosis, parakeratosis, and abundant inflammatory cells in the submucosa and lamina propria. The numbers of abcesses (arrows) and hyphal cells were appreciably lower in wild-type mice. Bars: A and B, 400 um; inset A and B, 50 um; C and D, 100 um.
Copyright This image is from Romani L, J Exp Med 1996 Apr 1;183(4):1345-55, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:79314
Associated
Alleles
Symbol Name
Il6tm1Poli interleukin 6; targeted mutation 1, Valeria Poli
Associated
Genotypes
Allelic Composition Genetic Background
Il6tm1Poli/Il6tm1Poli involves: 129S/SvEv * MF1

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory