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Phenotype Image Detail
Image
Caption Histological sections showing exencephaly in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos. A,C and E, Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos; B,D and F, control Brca1tm2.1Cxd/Brac1+ Gadd45atm1Ajf/Gadd45atm1Ajf embryos. A/B, C/D and E/F, E9.5, E10.5 and E12.5 embryos, respectively, showing that brains were not developed in mutant embryos. fb, forebrain; mb, midbrain; hb, hindbrain. Bar= 32 um for A-D and 64 um for E and F. A total of 30 embryos (E9.5, n = 15; E10.5, n = 10; and E12.5, n = 5) were examined.
Copyright This image is from Wang X, J Biol Chem 2004 Jul 9;279(28):29606-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:91673
Associated
Alleles
Symbol Name
Brca1tm2.1Cxd breast cancer 1; targeted mutation 2.1, Chu-Xia Deng
Gadd45atm1Ajf growth arrest and DNA-damage-inducible 45 alpha; targeted mutation 1, Albert J Fornace
Associated
Genotypes
Allelic Composition Genetic Background
Brca1tm2.1Cxd/Brca1tm2.1Cxd
Gadd45atm1Ajf/Gadd45atm1Ajf
involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory