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| Caption | Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos. A: E10.5 Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos are small and developmentally delayed. Photographs were taken immediately after dissection of littermates harvested from Nfe2l2tm1Ywk/Nfe2l2+ Nfe2l2tm1Ywk/Nfe2l2tm1Ywk intercrossing, and embryos were determined alive by the presence of a heartbeat. Shown is histologic analysis of E10.5 compound mutant embryos showing features of apoptosis observed in the fascial ganglion (b), developing brain (c), and neural tube (d). TUNEL stain of a control embryo (e) is compared with compound mutant embryos (f and g) showing extensive apoptosis. | ||||||
| Copyright | This image is from Leung L, J Biol Chem 2003 Nov 28;278(48):48021-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:86725 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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