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Phenotype Image Detail
Image
Caption Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos. A: E10.5 Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos are small and developmentally delayed. Photographs were taken immediately after dissection of littermates harvested from Nfe2l2tm1Ywk/Nfe2l2+ Nfe2l2tm1Ywk/Nfe2l2tm1Ywk intercrossing, and embryos were determined alive by the presence of a heartbeat. Shown is histologic analysis of E10.5 compound mutant embryos showing features of apoptosis observed in the fascial ganglion (b), developing brain (c), and neural tube (d). TUNEL stain of a control embryo (e) is compared with compound mutant embryos (f and g) showing extensive apoptosis.
Copyright This image is from Leung L, J Biol Chem 2003 Nov 28;278(48):48021-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:86725
Associated
Alleles
Symbol Name
Nfe2l1tm1Ywk nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Yuet Wai Kan
Nfe2l2tm1Ywk nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Yuet Wai Kan
Associated
Genotypes
Allelic Composition Genetic Background
Nfe2l1tm1Ywk/Nfe2l1tm1Ywk
Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
involves: 129X1/SvJ

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory