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Phenotype Image Detail
Image
Caption Krt14tm1Efu/Krt14tm1Efu mice exhibit gross blistering over their body surface due to cytolysis in the basal layer of the epidermis. (a) 2 day old mutant mouse. Note that the front limbs and paws of this mouse are severely blistered. This occurred frequently in mutant mice in response to mild physical trauma. (b) Semithin (0.75 um) sections of a mutant skin biopsy taken at 2 days of age, embedded in Epon and stained with toluidine blue. Note formation of intrabasal blister leading to separation of the epidermis from the underlying dermis (double-headed arrow). From bottom to top: B, basal layer; S, spinous layers; G, granular layer; S, stratum corneum, hf, hair follicle. Bar, 30 um.
Copyright This image is from Lloyd C, J Cell Biol 1995 Jun;129(5):1329-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:25763
Associated
Alleles
Symbol Name
Krt14tm1Efu keratin 14; targeted mutation 1, Elaine Fuchs
Associated
Genotypes
Allelic Composition Genetic Background
Krt14tm1Efu/Krt14tm1Efu involves: 129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory