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Phenotype Image Detail
Caption Histological analyses revealed multiple pathological findings in Thbdtm2Rdr/Thbdtm2Wlr Tg(Tek-cre)1Ywa/0 mice. (a) Intravascular thrombi in a peripheral vein (arrow) and the adjacent artery (arrowhead); hematoxylin and eosin (H&E) stain. (b) Intravascular thrombus in the liver, partially occluding a liver vein; H&E stain. (c and e) Trichrome stain of lung sections from mutant (c) and control (e) mice. Increased extracellular matrix content in the lung interstitium is associated with a marked destruction of the lung architecture and a loss of alveolar septa. (d and f) Trichrome stain of heart sections from mutant (d) and control (f) mice; multiple sites of myocardial fibrosis in the mutant heart. Original magnification is indicated at lower right.
Copyright This image is from Isermann B, J Clin Invest 2001 Aug;108(4):537-46 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:71269
Symbol Name
Tg(Tek-cre)1Ywa transgene insertion 1, Masashi Yanagisawa
Thbdtm2Rdr thrombomodulin; targeted mutation 2, Robert D Rosenberg
Thbdtm2Wlr thrombomodulin; targeted mutation 2, Harmut Weiler
Allelic Composition Genetic Background
involves: 129S2/SvPas * C57BL/6 * SJL

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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