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Phenotype Image Detail
Image
Caption Radiographs of the skeletal abnormalities in 7 month old Smad3tm1Cxd/Smad3tm1Cxd (-/-) mice. A and B: Whole-mount view of wild-type (+/+) and mutant skeletons. Mutant mice exhibited increased intensities in vertebral and knee joints (arrowheads). C-H: Enlarged views of knee (C and D), vertebral (E and F), and sternum joints (G and H). The increased density in mutant joints is caused by formation of extra bones (arrowheads). However, decreased bone densities were found in other areas of mutant bones compared with corresponding regions of wild-type mice.
Copyright This image is from Yang X, J Cell Biol 2001 Apr 2;153(1):35-46, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:68792
Associated
Alleles
Symbol Name
Smad3tm1Cxd SMAD family member 3; targeted mutation 1, Chu-Xia Deng
Associated
Genotypes
Allelic Composition Genetic Background
Smad3tm1Cxd/Smad3tm1Cxd involves: 129S6/SvEvTac

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory